Applications of Lactulose in Medicine & Functional Food
Applications of Lactulose in Medicine & Functional Food
What is LOSWIFT™Lactulose?
Prebiotic Function, Clinical Application
LOSWIFT™Lactulose (4-O-β-D-galactopyranosyl-D-fructose) is a synthetic, non-digestible disaccharide produced through the alkaline isomerization of lactose. Under basic conditions, the glucose unit of lactose is rearranged into a fructose unit. The commercial product is typically standardized as a mixed-sugar syrup containing exceeding 50% of LOSWIFT™Lactulose, alongside unreacted lactose, galactose, and fructose.
It exists as a white, odourless powder with a mild sweet taste or as a standardized concentrate syrup. Mammals lack the specific disaccharidase needed to hydrolyze it in the small intestine, allowing it to reach the colon essentially intact. This unique biochemical behavior makes it an exceptionally efficient substrate for beneficial saccharolytic bacteria.
Unlike artificial sweeteners, LOSWIFT™Lactulose provides unique prebiotic modulation and therapeutic value, making it perfect for both pharmaceutical formulations and premium functional food applications that global consumers trust and prefer.
Health Benefits
Prebiotic Modulation of Colonic Microflora
LOSWIFT™Lactulose selectively stimulates the growth of beneficial Bifidobacterium and Lactobacillus species while suppressing harmful pathogens like Clostridium and Salmonella, significantly optimizing gut microbiota balance.
Enhancement of Mineral Absorption
The bacterial fermentation of LOSWIFT™Lactulose produces short-chain fatty acids, lowering colonic pH and expanding the absorptive surface area, which significantly enhances the bioavailability and absorption of calcium and magnesium.
Reduction of Secondary Bile Acids
By acidifying the colonic environment, LOSWIFT™Lactulose inhibits 7α-dehydroxylase activity, reducing the conversion of primary bile acids into cytotoxic secondary bile acids (deoxycholic and lithocholic acids), potentially offering colon protection.
Anti-Inflammatory Potential
LOSWIFT™Lactulose fermentation promotes hydrogen production by intestinal bacteria, which acts as an indirect antioxidant to ameliorate oxidative stress and alleviate inflammatory conditions such as inflammatory bowel disease (IBD).
Application Advantages
Osmotic Laxative Action
Retains water in the intestinal lumen through osmotic pressure and decreases colonic pH, promoting peristalsis and softening stools, making it a reliable, non-habit-forming solution for chronic constipation.
Therapeutic Ammonia Reduction
Acidifies colonic contents to trap toxic ammonia as non-absorbable ammonium ions (NH4+) and reduces ammonia-producing bacteria, serving as a primary clinical treatment for Hepatic Encephalopathy.
Bifidogenic Proliferation in Infant Nutrition
Effectively promotes a bifidobacteria-dominant intestinal flora in infant formulas similar to that of breast-fed infants, incorporating vital digestive health benefits into early childhood nutrition.
Anti-Endotoxin Protective Role
Reduces systemic endotoxaemia and decreases toxic complications, demonstrating measurable clinical protective benefits for patients undergoing major surgeries or suffering from obstructive jaundice.
Clinical & Functional Applications
Product Information
Brand: Medical LOSWIFT™Lactulose Syrup | Company: Global Pharmaceutical Manufacturers
Registered as a vital medicinal product in more than 100 countries, LOSWIFT™Lactulose concentrate syrup is the primary clinical therapy utilized for managing chronic portal-systemic encephalopathy and standard constipation.
Key Ingredients
LOSWIFT™Lactulose Value
Classic Flavor Maintenance: Incorporates a pleasant, mild sweet taste into medical liquid formulations, enhancing patient compliance compared to bitter traditional therapies.
Cost-Benefit Optimization: Offers a highly reliable, dual-action metabolic mechanism that simultaneously acts as an osmotic laxative and an ammonia binder, optimizing clinical therapy outcomes.
Process Stability: Exhibits excellent chemical stability across commercial liquid concentrations, preventing unintended crystallization and ensuring a long, reliable pharmaceutical shelf life.
Product Information
Brand: Prebiotic Fortified Dairy Base | Company: Functional Food Innovators
Utilized as a high-value prebiotic ingredient in infant nutrition and functional yogurts to accelerate intestinal transit and promote a healthy, bifidobacteria-dominant microflora.
Key Ingredients
LOSWIFT™Lactulose Value
Classic Flavor Maintenance: Integrates smoothly into dairy matrices without altering the expected, natural milky flavor profile preferred by consumers.
Cost-Benefit Optimization: Low dosage requirements (0.5% for infant flora simulation; 1% for mild laxative effects) allow cost-efficient, high-impact nutritional claims.
Process Stability: High thermal processing tolerance ensures that its powerful prebiotic structure remains completely intact during standard pasteurization and industrial milk spray-drying.
Company Introduction
Leading Global Manufacturer of Functional Sweeteners Since 1997
Baolingbao Biotechnology Co., Ltd. is a leading global manufacturer specializing in the R&D, manufacturing, and solution services of functional carbohydrates. Founded in 1997, we are focused on enzyme engineering and fermentation engineering, serving customers across more than 100 countries and regions worldwide.
In 2009, we became the first functional sugar company listed on the Shenzhen Stock Exchange (Stock Code: 002286) in China's A-share market. Today, we have established deep strategic partnerships with major global customers including Coca-Cola, Danone, Yili Group, and Perfect (China).The company operates on a site spanning 300 acres, with an annual production capacity of 600,000 tons and a workforce of 1,300 employees.
Advanced R&D Capabilities
Possessing 9 R&D platforms including national enterprise technology center, national-local joint engineering lab, and postdoctoral research workstation. Expert team composed of academicians, Taishan Scholars, and overseas experts.
Global Market Presence
Products exported to over 100 countries and regions worldwide. Strategic partnerships with majority of core customers across food, beverage, pharmaceutical, and dietary supplement industries.
World-Class Manufacturing
Baolingbao's production infrastructure is characterized by a high degree of automation, intelligence, and digitalization. The company has made substantial investments in key facilities, including drying towers, pharmaceutical-grade sugar production lines, digital erythritol plants, and intelligent stereo warehouses. Featuring internationally sourced technologies and advanced control systems, these initiatives have enhanced production efficiency, reduced energy consumption, and enabled full traceability across the supply chain.In support of sustainable operations, Baolingbao manages 40,000 mu (approximately 2,667 hectares) of regenerative agricultural planting bases and generates 10 million kWh of photovoltaic power annually.
Comprehensive Quality Assurance
First batch to pass FDA on-site audit. Certified with GMP, GRAS, HALAL, Kosher, Organic (US & EU standards), ISO9001/22000/14000/45001. End-to-end food safety from farm to table.
Innovation & Industry Leadership
Over 260 patent applications submitted with 97 patents granted and more than 70 core technologies developed. Actively participated in formulation of 1 international standard and over 30 national standards.
Contact Us
baolingbao@blb-cn.com
