Lactulose: Exploring Multidimensional Applications in the Medical Field
Significantly Enhances Mineral Absorption
Antitumor and Immunomodulatory Effects
Anti-endotoxin Properties
Effective Treatment for Salmonella Carriers
Lactulose: Exploring Multidimensional Applications in the Medical Field
Introduction to Lactulose
Synthetic Disaccharide with Prebiotic Properties
Lactulose is a synthetic disaccharide composed of galactose and fructose linked by a β-1,4 glycosidic bond. It does not occur naturally in nature and is typically produced through the isomerization of lactose under alkaline conditions. As a prebiotic, lactulose possesses unique physicochemical properties and physiological activities, finding wide applications in the medical and food industries.
Health Benefits
Enhancement of Mineral Absorption
Lactulose can significantly augment the absorption of calcium, especially when the diet contains at least 0.3% calcium. Animal studies have shown that lactulose promotes the absorption and retention in the body of several minerals such as Ca, Mg, Zn, Cu, and Fe. Clinical trials have confirmed that lactulose enhances the absorptions of Ca and Mg, with significant increases observed with increasing amounts of lactulose administration.
Antitumor and Immunomodulatory Effects
The DNA-protective effect of lactulose has been demonstrated in human flora-associated rats. Many studies have shown numerous specific and nonspecific antitumour and immunological effects exerted by bifidobacteria. As most bifidobacteria metabolise lactulose, this immunological and antitumour effects of bifidobacteria can most likely be triggered by feeding with lactulose, showing efficacy in prevention of mammary and liver carcinogenesis.
Anti-endotoxin Properties
Lactulose has anti-endotoxin properties. Studies on patients with obstructive jaundice undergoing surgery showed that endotoxaemia was reduced in systemic blood samples of patients treated by lactulose. Animal experiments have also shown that oral lactulose administration reduced the mortality associated with endotoxin in obstructive jaundice and can prevent endotoxin-dependent complications.
Application Advantages
Treatment of Salmonella Carriers
Lactulose has shown potential as a powerful prebiotic in nontyphoid salmonella carrier treatment, used in dosages of up to 60 g per day. It leads to a sharp drop of the colonic pH, making the survival of salmonella difficult. Studies showed that after 4 weeks of lactulose treatment, the organisms were removed in 68.6% of patients, resulting in a shorter period of excretion compared to antibiotic treatment.
Unique Role in the Treatment of Inflammatory Bowel Disease
Lactulose effects on both bacteria and bacterial endotoxin provide a theoretical basis for its use in IBD treatment. Oral therapy causes increased production of low molecular weight organic acids in the colon with significant decrease in faecal pH, creating favourable conditions for Lactobacillus acidophilus growing. Lactulose may reduce pathogens, limit infections, decrease gut endotoxins, and regulate bowel habits, offering an alternative form of therapy for IBD.
Company Introduction
Leading Global Manufacturer of Functional Sweeteners Since 1997
Baolingbao Biotechnology Co., Ltd. is a leading global manufacturer specializing in the R&D, manufacturing, and solution services of functional carbohydrates. Founded in 1997, we are focused on enzyme engineering and fermentation engineering, serving customers across more than 100 countries and regions worldwide.
In 2009, we became the first functional sugar company listed on the Shenzhen Stock Exchange (Stock Code: 002286) in China's A-share market. Today, we have established deep strategic partnerships with major global customers including Coca-Cola, Danone, Yili Group, and Perfect (China).The company operates on a site spanning 300 acres, with an annual production capacity of 600,000 tons and a workforce of 1,300 employees.
Advanced R&D Capabilities
Possessing 9 R&D platforms including national enterprise technology center, national-local joint engineering lab, and postdoctoral research workstation. Expert team composed of academicians, Taishan Scholars, and overseas experts.
Global Market Presence
Products exported to over 100 countries and regions worldwide. Strategic partnerships with majority of core customers across food, beverage, pharmaceutical, and dietary supplement industries.
World-Class Manufacturing
Baolingbao's production infrastructure is characterized by a high degree of automation, intelligence, and digitalization. The company has made substantial investments in key facilities, including drying towers, pharmaceutical-grade sugar production lines, digital erythritol plants, and intelligent stereo warehouses. Featuring internationally sourced technologies and advanced control systems, these initiatives have enhanced production efficiency, reduced energy consumption, and enabled full traceability across the supply chain.In support of sustainable operations, Baolingbao manages 40,000 mu (approximately 2,667 hectares) of regenerative agricultural planting bases and generates 10 million kWh of photovoltaic power annually.
Comprehensive Quality Assurance
First batch to pass FDA on-site audit. Certified with GMP, GRAS, HALAL, Kosher, Organic (US & EU standards), ISO9001/22000/14000/45001. End-to-end food safety from farm to table.
Innovation & Industry Leadership
Over 260 patent applications submitted with 97 patents granted and more than 70 core technologies developed. Actively participated in formulation of 1 international standard and over 30 national standards.
Contact Us
baolingbao@blb-cn.com
