Applications of Lactulose in Healthcare and Food Industry
Bifidogenic prebiotic supporting beneficial gut microbiota
Osmotic laxative action for chronic constipation relief
Gold-standard therapy for hepatic encephalopathy management
Enhances intestinal calcium and magnesium absorption
Applications of Lactulose in Healthcare and Food Industry
What is LOSWIFT™Lactulose?
Synthetic Prebiotic Disaccharide
LOSWIFT™Lactulose (4-O-beta-D-galactopyranosyl-D-fructose) is a synthetic, non-digestible disaccharide produced almost exclusively through the alkaline isomerization of lactose. It appears as a white, odourless powder with a mild sweet taste, possessing a molar mass of 342.30 g/mol and a melting point of 169 °C.
Because mammals lack the specific disaccharidase required to hydrolyze it in the small intestine, LOSWIFT™Lactulose transits undigested to the colon. There, it serves as an efficient substrate for saccharolytic bacteria, particularly Bifidobacterium and Lactobacillus species, which ferment it into beneficial short-chain fatty acids.
This distinct biochemical property underpins its dual role as a high-value prebiotic ingredient in functional food formulations and as an active pharmaceutical substance registered in over 100 countries for indications such as chronic constipation and hepatic encephalopathy.
Health Benefits
Osmotic Laxative Action
Fermentation in the colon converts LOSWIFT™Lactulose into organic acids, lowering luminal pH and raising osmotic pressure to draw water into the gut. This increases stool bulk and accelerates intestinal transit, offering safe constipation relief without causing intestinal cramping or electrolyte imbalances.
Hepatic Encephalopathy Management
Stimulates bacterial growth to utilize nitrogen for protein synthesis while luminal acidification converts diffusible ammonia (NH3) into non-diffusible ammonium ions (NH4+). This prevents intestinal absorption of toxins, significantly reducing blood ammonia levels and improving cognitive performance in PSE patients.
Mineral Bioavailability Enhancement
Markedly enhances the intestinal uptake and retention of essential minerals, including calcium, magnesium, zinc, copper, and iron. Clinical trials confirm dose-dependent improvements in calcium and magnesium absorption, which support bone density and skeletal health without disrupting bone resorption rates.
Prebiotic & Immunomodulatory Function
Selectively promotes the proliferation of beneficial Bifidobacteria and Lactobacilli while suppressing pathogenic microbes like Clostridium, Salmonella, and Shigella. This metabolic activity lowers secondary bile acid production, reinforces the gut epithelial barrier, and helps reduce the risk of colon carcinogenesis.
Application Advantages
Functional Dairy & Infant Formula Optimization
Incorporating LOSWIFT™Lactulose into infant formula at concentrations of 0.5% to 1.0% successfully activates beneficial bifidobacteria colonization to mirror breast-fed infant microbiota. In bioyogurt manufacturing, it reduces incubation times, boosts viable probiotic counts, and delivers stable pediatric constipation relief without compromising sensory properties or product shelf life.
Probiotic Synergy & Isoflavone Bioconversion
Adding LOSWIFT™Lactulose to plant-based food matrices like soymilk selectively enhances the proliferation of strains such as Bifidobacterium longum and Bifidobacterium animalis. This synergistic fermentation boosts the enzymatic bioconversion of inactive soybean isoflavone glycosides into highly bioavailable active aglycones by up to 17%, maximizing the functional health value of plant formulations.
Antibiotic-Free Prebiotic Feed Applications
Serves as a high-performance, non-antibiotic feed additive in livestock health management by optimizing cecal and colonic microbial ecosystems. It supports endogenous beneficial bacteria, improves overall intestinal structural integrity, and inhibits pathogen colonization, directly addressing consumer demand for antibiotic-free and premium-quality animal products.
Non-Antibiotic Pathogen Eradication
Demonstrates clinical efficacy as a non-antibiotic therapeutic intervention for non-typhoid Salmonella carriers by inducing a severe pH drop in the colon that prevents pathogen survival. This action significantly shortens pathogen shedding duration without creating selective pressure for antibiotic resistance or disrupting systemic patient health.
Company Introduction
Leading Global Manufacturer of Functional Sweeteners Since 1997
Baolingbao Biotechnology Co., Ltd. is a leading global manufacturer specializing in the R&D, manufacturing, and solution services of functional carbohydrates. Founded in 1997, we are focused on enzyme engineering and fermentation engineering, serving customers across more than 100 countries and regions worldwide.
In 2009, we became the first functional sugar company listed on the Shenzhen Stock Exchange (Stock Code: 002286) in China's A-share market. Today, we have established deep strategic partnerships with major global customers including Coca-Cola, Danone, Yili Group, and Perfect (China).The company operates on a site spanning 300 acres, with an annual production capacity of 600,000 tons and a workforce of 1,300 employees.
Advanced R&D Capabilities
Possessing 9 R&D platforms including national enterprise technology center, national-local joint engineering lab, and postdoctoral research workstation. Expert team composed of academicians, Taishan Scholars, and overseas experts.
Global Market Presence
Products exported to over 100 countries and regions worldwide. Strategic partnerships with majority of core customers across food, beverage, pharmaceutical, and dietary supplement industries.
World-Class Manufacturing
Baolingbao's production infrastructure is characterized by a high degree of automation, intelligence, and digitalization. The company has made substantial investments in key facilities, including drying towers, pharmaceutical-grade sugar production lines, digital erythritol plants, and intelligent stereo warehouses. Featuring internationally sourced technologies and advanced control systems, these initiatives have enhanced production efficiency, reduced energy consumption, and enabled full traceability across the supply chain.In support of sustainable operations, Baolingbao manages 40,000 mu (approximately 2,667 hectares) of regenerative agricultural planting bases and generates 10 million kWh of photovoltaic power annually.
Comprehensive Quality Assurance
First batch to pass FDA on-site audit. Certified with GMP, GRAS, HALAL, Kosher, Organic (US & EU standards), ISO9001/22000/14000/45001. End-to-end food safety from farm to table.
Innovation & Industry Leadership
Over 260 patent applications submitted with 97 patents granted and more than 70 core technologies developed. Actively participated in formulation of 1 international standard and over 30 national standards.
Contact Us
baolingbao@blb-cn.com
