Applications of Lactulose in Medical & Healthcare Field
Passes intact to feed colonic bifidobacteria
Acts effectively as safe osmotic laxative
Traps and eliminates toxic blood ammonia
Provides anti-endotoxin protection in biliary surgery
Applications of Lactulose in Medical & Healthcare Field
What is LOSWIFT™Lactulose?
Synthetic Prebiotic Disaccharide with Multi-Functional Applications
Lactulose (4-O-beta-D-galactopyranosyl-D-fructose) is a synthetic disaccharide in which a galactose unit is joined to a fructose unit through a beta-1,4 glycosidic bond. Existing as a white, odourless crystalline powder with a mild sweet taste, LOSWIFT™Lactulose has a molar mass of 342.30 g/mol and a melting point around 169 °C.
Because human digestive enzymes cannot hydrolyse its glycosidic linkage, LOSWIFT™Lactulose passes intact through the upper gastrointestinal tract and reaches the colon, where it acts as a selective substrate for beneficial saccharolytic bacteria. This underlying mechanism supports its long-standing role as a prebiotic and pharmaceutical agent registered in over 100 countries.
Beyond traditional indications such as constipation and hepatic encephalopathy, the application scope of LOSWIFT™Lactulose has broadened significantly to encompass functional foods, clinical nutrition, and feed additives.
Health Benefits
Inhibition of Secondary Bile Acid Formation
By selectively promoting bifidobacteria and saccharolytic flora, LOSWIFT™Lactulose lowers colonic pH and alters the metabolic environment to reduce secondary bile acid concentrations. Clinical research demonstrates that sustained administration decreases faecal secondary bile acid excretion, increases wet stool weight, and acidifies the bowel environment to lower colonic exposure to cytotoxic bile salts.
Treatment of Constipation
As a widely approved osmotic laxative, LOSWIFT™Lactulose reaches the colon unchanged where bacterial fermentation produces low-molecular-weight organic acids like lactic and acetic acids. This raises intraluminal osmotic pressure, draws water into the bowel lumen, and stimulates intestinal peristalsis without causing systemic electrolyte imbalances or severe intestinal cramping.
Blood Ammonia Reduction & Hepatic Encephalopathy Support
Colonic acidification by LOSWIFT™Lactulose converts diffusible ammonia (NH3) into non-absorbable ammonium ions (NH4+) trapped for faecal excretion. Furthermore, it stimulates bacterial growth to incorporate nitrogen into microbial protein and directly suppresses bacterial enzymes responsible for ammonia generation, significantly improving cognitive function and health-related quality of life.
Anti-Endotoxin Protection in Obstructive Jaundice
LOSWIFT™Lactulose exhibits protective anti-endotoxin effects in surgical contexts like obstructive jaundice where bile salt absence allows bacterial translocation. Preoperative administration markedly lowers systemic endotoxin concentrations and serum creatinine levels, helping reduce endotoxin-dependent renal dysfunction and related postoperative complications.
Application Advantages
Advantages in Salmonella Clearance
High-dose LOSWIFT™Lactulose administration promotes pronounced colonic acidification that creates an inhospitable environment for Salmonella persistence. Clinical observations confirm that LOSWIFT™Lactulose significantly shortens the bacterial shedding duration compared to conventional antibiotic treatments, making it a valuable non-antibiotic intervention for antimicrobial stewardship strategies.
Value in Inflammatory Bowel Disease (IBD) Management
LOSWIFT™Lactulose enhances low-molecular-weight organic acid production, suppressing pathogenic genera while favoring Lactobacillus acidophilus proliferation. It reduces gut-derived endotoxin absorption, functions as an indirect antioxidant by stimulating colonic hydrogen production to alleviate mucosal oxidative stress, and lowers relapse rates during long-term maintenance.
Enhancement of Mineral Absorption & Bone Health
Fermentation-induced luminal acidification solubilizes mineral salts, significantly elevating the bioavailability and mucosal transport of essential minerals such as calcium and magnesium. Research confirms that increased LOSWIFT™Lactulose intake promotes urinary mineral excretion ratios, improves bone mineralization, and enhances femoral structural strength in clinical and nutritional applications.
Company Introduction
Leading Global Manufacturer of Functional Sweeteners Since 1997
Baolingbao Biotechnology Co., Ltd. is a leading global manufacturer specializing in the R&D, manufacturing, and solution services of functional carbohydrates. Founded in 1997, we are focused on enzyme engineering and fermentation engineering, serving customers across more than 100 countries and regions worldwide.
In 2009, we became the first functional sugar company listed on the Shenzhen Stock Exchange (Stock Code: 002286) in China's A-share market. Today, we have established deep strategic partnerships with major global customers including Coca-Cola, Danone, Yili Group, and Perfect (China).The company operates on a site spanning 300 acres, with an annual production capacity of 600,000 tons and a workforce of 1,300 employees.
Advanced R&D Capabilities
Possessing 9 R&D platforms including national enterprise technology center, national-local joint engineering lab, and postdoctoral research workstation. Expert team composed of academicians, Taishan Scholars, and overseas experts.
Global Market Presence
Products exported to over 100 countries and regions worldwide. Strategic partnerships with majority of core customers across food, beverage, pharmaceutical, and dietary supplement industries.
World-Class Manufacturing
Baolingbao's production infrastructure is characterized by a high degree of automation, intelligence, and digitalization. The company has made substantial investments in key facilities, including drying towers, pharmaceutical-grade sugar production lines, digital erythritol plants, and intelligent stereo warehouses. Featuring internationally sourced technologies and advanced control systems, these initiatives have enhanced production efficiency, reduced energy consumption, and enabled full traceability across the supply chain.In support of sustainable operations, Baolingbao manages 40,000 mu (approximately 2,667 hectares) of regenerative agricultural planting bases and generates 10 million kWh of photovoltaic power annually.
Comprehensive Quality Assurance
First batch to pass FDA on-site audit. Certified with GMP, GRAS, HALAL, Kosher, Organic (US & EU standards), ISO9001/22000/14000/45001. End-to-end food safety from farm to table.
Innovation & Industry Leadership
Over 260 patent applications submitted with 97 patents granted and more than 70 core technologies developed. Actively participated in formulation of 1 international standard and over 30 national standards.
Contact Us
baolingbao@blb-cn.com
